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Запойные состояния характеризуются значительными изменениями в физиологии и биохимии организма. Хроническое употребление алкоголя приводит к нарушениям метаболизма нейротрансмиттеров, особенно гамма-аминомасляной кислоты (ГАМК) и глутамата. Алкоголь действует как депрессант центральной нервной системы (ЦНС), усиливая тормозную функцию ГАМК и подавляя возбуждающее действие глутамата.
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